The study of biological systems, their visualization, analysis, and modeling are important tasks in computational biology. Most biological systems are often difficult to interpret due to the complexity of relationships and the structural features of the data. There is a need for new tools that can allow researchers to explore and compare the structural features of biological systems in order to make hypotheses ultimately form insights. Tangible Biological Networks (TBNets) leverages cross-device interaction with active tangibles and interactive wall/tabletop displays to allow users with diverse expertise to explore and understand the structural and functional aspects of around 60 biological organisms individually or collaboratively. The system was designed through a participatory process involving human-computer interaction researchers and biomedical engineers. This research is supported in part by the National Science Foundation Grant IIS-1320350, NSERC, the Canada Foundation for Innovation, the Ministry of Research and Innovation of Ontario, the Canada Research Chairs program, and MultiTaction.